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There- fore, from a drruggability position, it is portentous to select working groups that maximize the unionized fraction at physio- sound pH without compromising other attributes such as solubil- ity, sturdiness and potency. See Alkie cardiac myopathy Mutations expansion regulatory gene targets in smokers, 310 induction by means of genotoxic carcinogens, 234 induction during booze toxicity, 268 macro-versus microlesions, 242 potency of tobacco smoke types, 291 post in regulatory gene dysfunction, 239 screening via Ames Salmonella test, 243 site-specific mutagenesis studies, 235 Mycotoxins contribution to nephrotoxicity, 185 role in crop spoiling, 172 toxicological properties, 173 N NADPH-cytochrome P450 reductase, 77 NADPH oxidase, 109 National toxicology program (NTP) Bisphenol A valuation (CERHR), 215 setting up, 17 function in carcinogen testing, 244 Index The using software is examination version. 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